Is the brand new CORONA VIRUS Pressure solely restricted as much as the UK proper now?
No. Variant VUI-202012/01 has been discovered that in Italy, Gibraltar, Denmark, the Netherlands and Australia. There are additionally lot of unconfirmed stories of an analogous pressure being present in France and South Africa, however no-one’s confirmed that they’re equivalent but.
The Italian and Australian ones are traceable from there individuals who had been within the UK. The others, not a lot.
The place else would possibly it’s? Effectively, it’s moderately suspicious that the UK (United Kingdom), so intently adopted by Denmark have among the highest sequencing capabilities on the planet for these kind of genomes, and do a whole lot of random testing. The UK has put collectively a large effort to sequence the genomes of round 10% of all constructive check samples, which so far as I’m conscious is world-leading. South Africa is the one place on the continent that has important capability to check for it in any respect.
This isn’t saying it’s widespread … it’s simply that if it was, the above checklist are among the more than likely nations to search out it.
Will the CORONA VIRUS-19 vaccines are developed by Pfizer/BioNTech and Moderna construct immunity that in opposition to different flue viruses since they use the expertise of mRNA to focus on the spike protein and which are additionally current in them?
Disclosure, I’ve labored on a unique numbers of spike applied sciences for influenza
To start with, sure Moderna and Pfizer/BioNTech are engaged on mRNA vaccines for the flue. That’s the reason Bio-NTech is even within the race. Two or extra years in the past, Pfizer and Bio-NTech determined that to accomplice up on a mRNA vaccine for flu which is why they’ve a analysis and monetary relationship with one another previous to the beginning of CORONA VIRUS-19.
However the flue spike is a ache within the –. And so Many groups have tried to construct the hemagglutinin (HA) spike protein together with my very own . Just like the COVID-19, the HA spike can also be a trimmer and like COVID-19 spike, generates antibodies to the top area. However as depicted within the under buildings, a lot of the variability of the virus seems on the top area versus the stem area.
Construction of the CORONA VIRUS Spike
For relative measurement, the CORONA VIRUS spike protein is a bit bigger than the flu HA spike.
The final problem with the technology of a broadly neutralizing antibody in opposition to the flu is the issue of eliciting antibodies in opposition to the conserved spike versus the extra variable head. Making the stem protein alone has been an enormous downside in of itself and is the topic of a number of biophysical research. Moderna discovered for MERS that they may stabilize the spike utilizing a pair of proline substitutions and leveraged that information to make the coronavirus spike however these advances haven’t been but discovered for the HA stem.
Plus, there may be the entire value challenge. Cell-based flu vaccines like FluBlok and Flucelvax exists however apparently value an excessive amount of which is why they aren’t closely used. mRNA vaccines prices one other order of magnitude greater than cell-based flu vaccines so if we’re not utilizing the cell-based manufacturing methods, well being care suppliers are going to have a troublesome time transferring to the newer mRNA vaccines purely due to prices even when the cell-based flus are simpler.